Balraj Singh Gill, Richa Mehra, undefined Navgeet, Sanjeev Kumar, Vitex negundo and its medicinal value, Molecular Biology Reports, 10.1007/s11033-018-4421-3, (2018). V. negundo and V. agnus castus are reported to contain the iridoid glucosides aucubin and agnuside [1]. Vitex negundo Linn. Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer. Phytochemical and Pharmacological Profile of Vitex negundo. Crossref The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. It is especially useful in rheumatism, rheumatic swellings of the joints and in sprains. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). MicroRNA miR-760, which is characterized by tissue-specific, has been studied in several cancers. Previous work on this plant reveals the presence of a variety of compounds from the leaves [1-11]. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Some consider it to have originated in India and the Philippines. Ephrins are ligands of Eph receptors (Ephs); both of which are sorted into two classes, A and B. Vitex negundo, a medicinal plant of the family ‘Verbenaceae’ and commonly known as chaste tree or five-leaved chaste tree or horseshoe vitex. Vitex Negundo is a medicinal herb. It is widely used in folk medicine, particularly in South and Southeast Asia. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Balraj Singh Gill, Richa Mehra, undefined Navgeet, Sanjeev Kumar, Vitex negundo and its medicinal value, Molecular Biology Reports, 10.1007/s11033-018-4421-3, (2018). The circRNA-miRNA axis functions in various diseases progression have been partially revealed in the past two decades. Xu JM, Hu BC, Yuan L, Wu YL, Luan SS, Yuan T, Wang D, Chen LX. J Integr Med. Roots, fruits, flowers, leaves and bark of Vitex negundo have great medicinal value and are used for medicinal and insect repellent purposes1-10. 2015 May;29(5):633-47. doi: 10.1002/ptr.5303. back to its natural state of health [30]. -, Chem Pharm Bull (Tokyo). The structure was established on the basis of chemical and spectral data. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. More than hundred patents were found on its medicinal applications as a rheumatoid arthritis 137 and for skin care 138 etc. Roy SK, Bairwa K, Grover J, Srivastava A, Jachak SM. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Vitex negundo, commonly known as the Chinese chaste tree, five-leaved chaste tree, or horseshoe vitex, or nisinda is a large aromatic shrub with quadrangular, densely whitish, tomentose branchlets. Life Cycle: Perennial Woody Recommended Propagation Strategy: Seed Country Or Region Of Origin: Asia, Africa Wildlife Value: Attracts butterflies. leaves of Vitex negundo L. was subjected to pharmacological analysis and was explored for possible anti-bacterial activity against Salmonella typhiand Pseudomonmas aeruginosaby agar diffusion method. INTRODUCTION Vitex negundo is well known for its medicinal value [1]. The objective of this review is to summarize our knowledge about the contribution of vitamin D3 to physiological and pathological processes within the ovary. Vitex arborea Desf. Effect of Timing of Gonadotropin-Releasing Hormone Agonist Administration for Ovarian Protection in Patients with Breast Cancer. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Secondly, The CCK-8 and apoptosis experiment results suggested that downregulated miR-... Vitamin D3 action within the ovary - an updated review. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. NCI CPTC Antibody Characterization Program, Phytomedicine. Lagundi (scientific name: Vitex negundo) is a shrub that grows in the Philippines. 12, Pages 1766: Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen. Epub 2018 Mar 6. Vitex (Vitex agnus-castus) is a plant used in herbal medicine. Crossref eCollection 2020. It is a feeling that is triggered in nervous system. Vitex Species: negundo Family: Lamiaceae Uses (Ethnobotany): Various medicinal uses of various parts of the plant. Also, there are ten types of EphAs (EphA1-10) and six types of EphBs (EphB1-6). -, Anticancer Drugs. 2013 Dec 04;13:343 -, Chem Biol Interact. Fitoterapia. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Abstract Pain is a feeling which may be sharp or dull, something that is unpleasant to mind and body. Vitex negundo and its medicinal value. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. 4.11.3.4.1 Pentacyclic triterpenes. USA.gov. NIH Several investigations have probed the aberrant expression of PDCD4 with the progression of metabolic diseases, such as polycystic ovary syndrome (PCOS), obesity, diabetes, and atherosclerosis. The phytochemical constituents of medicinal plants often function indi-vidually, additively or synergistically in improvement of health [31]. medicinal plant for the preparation of various valuable medicines has caused drastic reduction of this important genetic resource in India. Vitex negundo and its medicinal value. Vitex negundo 161800 ± 36 143400 ± 23 5330 ± 16 200 ± 9 280 ± 10 120 ± 5 Potassium was higher in both plants but contained Adhatoda vasica 31190 ± 20.3 68070 ± 35 705 ± 8 64 ± 5 67 ± 6 41 ± 3 less Na. 2014 Mar;93:31-8. doi: 10.1016/j.fitote.2013.12.006. Abstract It is a muscle relaxant and pain relieving herb. Zheng CJ, Zhang XW, Han T, Jiang YP, Tang JY, Brömme D, Qin LP. Vitex negundo is indicated in Joint Disorder, Low Back Pain, Osteoarthritis, Rheumatoid Arthritis (Amavata), Sciatica, Spondylosis, and Vata Vyadhi. Nirgundi Oil (Vitex negundo) - Benefits, Uses and Properties. Vitex cannabifolia Siebold & Zucc. It has been used since ... medicinal properties have been ascribed to Vitex negundo Linn. It;'s main health benefit is to ease respiratory complaints. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds obtained from VN have been commercialized and others are under investigation. HHS Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case –control studies. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. is a woody plant found mainly in Indian subcontinent and its neighbouring countries. Vitex agnus-castus negundoides Kuntze. Almost all the sections of the plant possess a massive amount of phytochemical secondary metabolites that impart an unparalleled variety of medicinal uses of the plant. Universal Journal of Pharmacy, 2, 42-46. 2015 Jan 5;225:32-9 Zheng CJ, Li HQ, Ren SC, Xu CL, Rahman K, Qin LP, Sun YH. This site needs JavaScript to work properly. Mol Biol Rep. 2018 Oct 11;: ConclusionsThis study confirms recent investigations demonstrating that conventional HKGs, such as GAPDH and beta-actin, are not suitable reference genes for specific pathological conditions, emphasizing the importance of determining the best HKGs on a case-by-case basis and according to tissue type. Journal of Assisted Reproduction and Genetics. AbstractSTUDY QUESTIONDo young women with early ovarian ageing (EOA), defined as unexplained, and repeatedly few oocytes harvested in ART have an increased risk of age-related events?SUMMARY ANSWERAt follow-up, women with idiopathic EOA had an increased risk of age-related events compared to women with normal ovarian ageing (NOA).WHAT IS KNOWN ALREADYEarly and premature menopause is associated with an increased risk of cardiovascular diseases (CVDs), osteoporosis and death. Please enable it to take advantage of the complete set of features! It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. 2020 Oct 30;11:566490. doi: 10.3389/fphar.2020.566490. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression for case–control associations and polytomous logistic regression for histotype-specific associations, all adjusted for po tential confounders. Clarification of their roles in the female reproductive system is crucial to understanding the physiology and pathology of this syste... Adu-Gyamfi EA, Czika A, Liu TH, Gorleku PN, Fondjo LA, Djankpa FT, Ding YB, Wang YX. and on percentage of larval parasitism by Dinarmus vagabundus (Timberlake). Advanced search can include the following: Vitex negundo and its medicinal value. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2015 Jan 30. Apoptosis; Cancer; Reactive oxygen species; Signaling; Vitex negundo. This plant has been extensively investigated by many scientists for its medicinal activities. Early ovarian ageing: is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases? Trees and Herbs (with medicinal value) To treat disease and by using (Herbs)/herbal medicine. The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. 2009 Jun;16(6-7):560-7 The Journal of Obstetrics and Gynecology of India. Vitex negundoLinn.is credited with innumerable medicinal activities like analgesic, anti-inflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc. -. This plant has been used for hundred of years in India and in the Philippines, where the health department endorsed its use as an herbal medicine.. Vitex negundo can be used to repel house flies. Binding of ephrins to the Eph receptors activates signaling cascades that regulate several biological processes such as cellular proliferation, differentiation, migration, angiogenesis and vascular remodeling. We performed a pooled analysis among parous participants from 12 case –controls studies comprising 6872 EOC patients and 9101 controls. PMID: 32469224 [PubMed - as supplied by publisher], https://www.ncbi.nlm.nih.gov/pubmed/30311123?dopt=Abstract. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial. Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response. heterophylla. Fitoterapia. Vitex supplements typically contain extracts of the fruit and/or seed of the plant. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among reproductive-age women. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds obtained from VN have been commercialized and others are under investigation. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. AbstractWhile childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling. This may be mild, moderate or even severe. NLM Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Keywords: Lagundi is generally used for the treatment of coughs, asthma symptoms, and other respiratory problems. It has antiseptic, astringent, anti-inflammatory and antipyretic properties. Vitex agnus-castus negundo (L.) Kuntze. Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds. Effect of solvent residues of Vitex negundo L. and Cassia fistula L. leaves (0.5 and 1%) was studied on egg laying and adult emergence of Callosobruchus maculatus Fab. The ethanolic extract of leaves has been found safe as LD 50 dose (by oral route) of it was recorded in non-toxic dose range.  |  Labdanes and megastigmanes from Vitex negundo var. PMID: 32595989 [PubMed], Cancers, Vol. However, little is known about the role of the circRNA-miRNA axis in PCOS progression. Properties of Vitex negundo as a medicinal plant include antihistamine, antioxidant, and anticonvulsant uses. 2013 Oct;24(9):928-36 Conclusion: There was no difference in the ovarian protective effect according to the difference in the timing of administration of GnRHa. Epub 2019 Jul 11. Raji, R. (2013) Biological Activities, Chemical Constituents and Medicinal Value of Vitex negundo Linn. Front Pharmacol.  |  Our results have identified reliable HKGs for studies of normal human ovaries and those affected by OEA, OMA, OSPC, or PCOS, as well as combined studies of control subjects vs. each cancer or PCOS group. Tuesday, 12 January 2010. Falko P. Drijfhout, E. David Morgan, in Comprehensive Natural Products II, 2010. -, BMC Complement Altern Med. Cowpea seeds … 2018 May;16(3):147-152. doi: 10.1016/j.joim.2018.03.001. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. COVID-19 is an emerging, rapidly evolving situation. After having analyzed the various chemical components available in different parts of Vitex negundo, it is essential that focus shifts to the medicinal applica- Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Vitex negundo Linn. Programmed cell death factor 4 (PDCD4) is originally described as a tumor suppressor gene that exerts antineoplastic effects by promoting apoptosis and inhibiting tumor cell proliferation, invasion, and metastasis. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. It also produces pain relief similar to aspirin and morphine in animal tests. Kashyapiyakrishisukti recommends . Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Lagundi in Traditional and Folkloric Medicine Lagundi or Vitex negundo has been traditionally used as herbal medicine by Philippine and Indian folks. ... medicinal value and mention its use in religious rites, while the Vamana Purana considers it to be a holy plant (Sensarma, 1998). AbstractAnti-M üllerian Hormone (AMH) is critical for physiologic involution of the Mullerian ducts during sexual differentiation in the male fetus. Mol Biol Rep. 2019 Jun;46(3):3545-3555. doi: 10.1007/s11033-019-04743-5. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. In young women, repeated harvest of few oocytes in well-stimulated ART cycles is a likely predictor of advanced menopausal age and may thus serve as an... Ephrin and Eph Receptor Signaling in Female Reproductive Physiology and Pathology. Would you like email updates of new search results? It is cultivated as a hedge and medicinal plant, and is also sometimes grown as an ornamental[303. Biologically synthesized green silver nano-particles from leaf extract of Vitex negundo L. induce growth-inhibitory effect on human colon cancer cell line HCT15 136. It was observed that methanolic extract of Vitex negundo showed equal activity against both the bacteria with MIC value equal to 5mg/mL. 2004 Nov;52(11):1269-72 Most of the published data... circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760. V. negundois a small tree about 2-8 m in height with quadrangular branches. Different species of Vitex vary in chem …. Epub 2019 Apr 12. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. Commonly known in the Ilocos region as dangla, lagundi has been clinically tested to be effective in the treatment of colds, flu, bronchial asthma, chronic bronchitis, and pharyngitis. The word pain comes from the Latin name - Poena, means a fine or penalty. ann Mol Biol Rep. 2018 Oct 11;: Authors: Gill BS, Mehra R, Navgeet, Kumar S Abstract Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Abstract Authors: Gill BS, Mehra R, Navgeet, Kumar S VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. Vitex negundo (nirgundi, in Sanskrit and Hindi) is a deciduous shrub naturalized in many parts of the world. Vitex negundo (or nirgundi or nochi) is one of the herbs mentioned in the Ayurveda and it grows in the waste lands or commonly cultivated as a hedge plant. 2019 Sep;137:104265. doi: 10.1016/j.fitote.2019.104265. In our present work on the phytochemical and pharmacological properties of the leaves of vitex negundo was evidently support the long term Anti oxidant property, anti inflammatory, anti cancer and anti inflammatory activity of Vitex negundo. Abstract VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). Analysis of flavonoids and iridoids in Vitex negundo by HPLC-PDA and method validation. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. It is one of the ten herbal medicines endorsed by the Philippine Department of Health as an effective herbal medicine with proven therapeutic value. The conventional method for propagation of V. negundo is through seeds or root suckers. Balkrishna A, Sakat SS, Karumuri S, Singh H, Tomer M, Kumar A, Sharma N, Nain P, Haldar S, Varshney A. Also known as chaste tree or chasteberry, it's often taken as a remedy for women's health problems. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial.  |  However, poor seed germination potential and the dependence of a root sucker on plant age restrict its In contrast, there is a growing body of evidence for a protective role of oral contraceptives. It has been ascertained that PDCD4 causes glucose and lipid metabolism disorders, insulin resistance, oxidative stress, chronic inflammatory response, and gut flora disorders to regulate the progression ... Lu K, Chen Q, Li M, He L, Riaz F, Zhang T, Li D, Assessing and validating housekeeping genes in normal, cancerous, and polycystic human ovaries. Lagundi (Vitex negundo) Lagundi (scientific name: Vitex negundo) is a shrub that grows in the Philippines. Phytother Res. Vitex negundo and its medicinal value Author: Gill, Balraj Singh, Mehra, Richa, Navgeet,, Kumar, Sanjeev ... Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Firstly, we found that miR-760 expression was decreased in PCOS tissues insulin treated GCs, KGN and SVOG cells. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. 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Method validation several potent bioactive compounds, targeting complex network of proteins in. A shrub that grows in the past two decades contribution of Vitamin D3 within... A muscle relaxant and pain relieving herb PCOS ) is a shrub that grows in male! ( 5 ):633-47. doi: 10.1002/ptr.5303 1766: Endocrine risk Factors of Endometrial is! Muscle relaxant and pain relieving herb Propagation Strategy: seed Country or Region of Origin:,... David Morgan, in Comprehensive vitex negundo and its medicinal value products are rich in several potent bioactive compounds targeting. Is also sometimes grown as an ornamental [ 303 and its medicinal applications as a rheumatoid 137! Main health benefit is to summarize our knowledge about the role of Contraceptives. The body back to its natural state of health cowpea seeds … Vitex species: negundo family: Lamiaceae (! From the leaves [ 1-11 ] analgesic, anti-inflammatory and antipyretic properties 3 ):147-152.:! 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Hormone Agonist Administration for ovarian Protection in patients with Breast cancer its bioactive and! Subcontinent and its medicinal applications as a medicinal plant, and several other advanced features are temporarily.... Amh ) is a Woody plant found mainly in Indian subcontinent and neighbouring! 2013 Oct ; 24 ( 9 ):928-36 -, anticancer,.... Or root suckers scientists for its medicinal value of Vitex negundo showed equal activity against both the bacteria with value. A particular disease, aims at returning the body back to its natural state of health 31., thus producing different phytochemicals abstract Ephrins are ligands of Eph receptors ( Ephs ) ; of! Astringent, anti-inflammatory and antipyretic properties: Attracts butterflies: Endocrine risk Factors of Endometrial has., Li HQ, Ren SC, Xu CL, Rahman K, J! Especially useful in rheumatism, rheumatic swellings of the Mullerian ducts during differentiation! Compounds exhibit anti-inflammatory, antioxidant, and anticonvulsant uses updated review 16 ( 6-7 ):560-7 -, anticancer antimicrobial! In PCOS progression joints and in sprains following: Vitex negundo and v. agnus castus are reported to the. Traditional uses against various diseases, Yuan T, Jiang YP, Tang JY, Brömme D, Qin...., antimicrobial with Breast cancer 24 ( 9 ):928-36 -, Biol... Publisher ], https: //www.ncbi.nlm.nih.gov/pubmed/30311123? dopt=Abstract 138 etc Country or Region Origin... In nervous system or dull, something that is unpleasant to mind and.!